exRNAdisease

Entry Detail

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General Information

Database ID: exR0442784 RNA Name: TPM4 RNA Type: mRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 16067021 End Site(bp): 16103002 External Links: ENSG00000167460

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AAMDC chr11 77821109 77918432 + AAMP chr2 218264123 218270257 - AARSD1 chr17 42950526 42964498 - ABL1 chr9 130713016 130887675 + AC004922.1 chr7 99325879 99394653 + AC007192.1 chr19 18153158 18178117 + AC048338.1 chr12 122207779 122266423 - AC138696.1 chr8 143247110 143276403 + AC245033.1 chr15 82536788 82573194 - ACLY chr17 41866917 41930542 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - ADCY5 chr3 123282296 123449758 - ADCY6 chr12 48766194 48789037 - ADIPOR2 chr12 1688574 1788674 + ADPGK chr15 72751369 72785846 - ADRM1 chr20 62302093 62308862 + AGAP3 chr7 151085831 151144436 + AHCY chr20 34280268 34311802 - AKT2 chr19 40230317 40285536 - AL136454.1 chr1 192716132 192716653 + AL365205.1 chr6 41780349 41790141 + ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-139-5p chr11 72615102 72615124 - hsa-miR-185-5p chr22 20033153 20033174 + hsa-miR-1270 chr19 20399320 20399342 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008969.1 chr19 58002061 58011232 + AC016876.2 chr17 7581964 7584086 - AC026362.1 chr12 122975320 122982907 + AC026464.2 chr16 69463844 69466264 + AC079807.1 chr2 47905678 47907810 + AC099343.3 chr4 184471924 184472609 - AC132217.1 chr11 2129121 2129964 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.