exRNAdisease

Entry Detail

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General Information

Database ID: exR0443389 RNA Name: USP22 RNA Type: mRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 20999596 End Site(bp): 21043760 External Links: ENSG00000124422

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AARS2 chr6 44298731 44313347 - ABCB1 chr7 87503017 87713323 - AC005726.1 chr17 28455752 28614185 - AC008581.2 chr5 77030902 77152155 + AC008695.1 chr5 131425891 131796983 - AC010422.3 chr19 12643831 12648397 - AC138811.2 chr16 18788063 18801519 - ACBD3 chr1 226144679 226186741 - ACIN1 chr14 23058564 23095614 - ACLY chr17 41866917 41930542 - ADH5 chr4 99070978 99088801 - ADSL chr22 40346500 40390463 + AGGF1 chr5 77029251 77065234 + AHCY chr20 34280268 34311802 - AKR1B1 chr7 134442356 134459284 - AL022238.4 chr22 40346529 40410054 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-148b-3p chr12 54337278 54337299 + hsa-miR-485-5p chr14 101055427 101055448 + hsa-miR-650 chr22 22822791 22822811 + hsa-miR-371a-5p chr19 53787680 53787699 + hsa-miR-616-3p chr12 57519183 57519204 - hsa-miR-665 chr14 100875075 100875094 + hsa-miR-1321 chrX 85835832 85835849 + hsa-miR-4508 chr15 23562107 23562123 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC006064.5 chr12 6510275 6510522 + AC007952.4 chr17 19112000 19112636 - AC011445.1 chr19 39314651 39320858 - AC016876.2 chr17 7581964 7584086 - AC026362.1 chr12 122975320 122982907 + AC067852.1 chr17 42536510 42562062 + AC067930.1 chr8 143579636 143580670 + AC087190.3 chr16 9104848 9113181 + AC111170.2 chr17 77469162 77472770 - AC133644.3 chr2 87455476 87767359 + AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.