exRNAdisease

Entry Detail

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General Information

Database ID: exR0443750 RNA Name: XRCC6 RNA Type: mRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 41621119 End Site(bp): 41664048 External Links: ENSG00000196419

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AASDHPPT chr11 106075501 106098699 + ABR chr17 1003518 1229738 - ABRAXAS1 chr4 83459517 83523348 - AC005020.2 chr7 99558695 99607810 + AC010132.3 chr7 42909273 42932174 - AC010422.3 chr19 12643831 12648397 - AC068946.1 chr2 219075329 219170827 - AC099811.2 chr17 42119674 42154916 - AC120057.2 chr17 7240427 7244635 - ACADVL chr17 7217125 7225266 + ACOT8 chr20 45841721 45857405 - ACTN1 chr14 68874143 68979440 - ACTR1A chr10 102461881 102502712 - ADAM10 chr15 58588809 58749791 - ADAM15 chr1 155050566 155062775 + ADCY3 chr2 24819169 24919839 - AKR1B1 chr7 134442356 134459284 - AL358113.1 chr9 69035747 69255187 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-17-5p chr13 91350618 91350640 + hsa-miR-18a-5p chr13 91350756 91350778 + hsa-miR-205-5p chr1 209432166 209432187 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC079781.5 chr7 97851688 97972985 - AC093157.1 chr1 101025844 101090513 + AC144548.1 chr12 110387463 110445548 - AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.