Entry Detail


General Information

Database ID:exR0510759
RNA Name:ABCB1
RNA Type:mRNA
Chromosome:chr7
Starnd:-
Coordinate:
Start Site(bp):87503017End Site(bp):87713323
External Links:ENSG00000085563



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABCB4
chr7
87401697
87480435
-
ATP8A1
chr4
42408373
42657105
-
ATRAID
chr2
27212027
27217178
+
LAS1L
chrX
65512582
65534775
-
NUAK1
chr12
106063340
106140033
-
NUDCD3
chr7
44379119
44490658
-
PIEZO1
chr16
88715338
88785220
-
RFX7
chr15
56087280
56245082
-
SLC41A2
chr12
104802553
104958744
-
TRIM44
chr11
35662775
35818007
+
USP22
chr17
20999596
21043760
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC008669.1
chr5
122832356
122834533
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.