Entry Detail


General Information

Database ID:exR0510762
RNA Name:ABCB4
RNA Type:mRNA
Chromosome:chr7
Starnd:-
Coordinate:
Start Site(bp):87401697End Site(bp):87480435
External Links:ENSG00000005471



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABCB1
chr7
87503017
87713323
-
AP1G2
chr14
23559565
23568070
-
BASP1
chr5
17065598
17276843
+
CENPV
chr17
16342534
16353656
-
CLDN6
chr16
3014712
3020071
-
CUL5
chr11
108008898
108107761
+
DDX5
chr17
64498254
64508199
-
EIF5A
chr17
7306999
7312463
+
FXR2
chr17
7591230
7614897
-
HNRNPDL
chr4
82422564
82430408
-
HSPA8
chr11
123057489
123063230
-
HTATSF1
chrX
136497079
136512346
+
KIF5B
chr10
32009015
32056425
-
MAF1
chr8
144104461
144107611
+
NUAK1
chr12
106063340
106140033
-
PAM
chr5
102753981
103031105
+
PHF14
chr7
10973336
11169630
+
RPL5
chr1
92832013
92841924
+
SERF2
chr15
43777087
43802589
+
SLC39A1
chr1
153959099
153968184
-
SNX18
chr5
54517759
54546586
+
SPOCK2
chr10
72059034
72089032
-
STX7
chr6
132445867
132513198
-
TMEM167A
chr5
83052846
83077863
-
TPT1
chr13
45333471
45341370
-
ZNF136
chr19
12163064
12189871
+
ZNF385A
chr12
54369133
54391298
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:NA
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.