Entry Detail


General Information

Database ID:exR0510774
RNA Name:ABCC5
RNA Type:mRNA
Chromosome:chr3
Starnd:-
Coordinate:
Start Site(bp):183919934End Site(bp):184017939
External Links:ENSG00000114770



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
VAPA
chr18
9914002
9960021
+
DGKQ
chr4
958887
986895
-
STRADA
chr17
63682336
63741986
-
POFUT1
chr20
32207880
32238658
+
DSTN
chr20
17570075
17609919
+
EEF1D
chr8
143579697
143599541
-
STRA6
chr15
74179466
74212267
-
WDR43
chr2
28894667
28948219
+
TMEM63A
chr1
225845536
225882380
-
OBSL1
chr2
219550728
219571859
-
RITA1
chr12
113185526
113192368
+
MKRN1
chr7
140453033
140479536
-
BSG
chr19
571277
583493
+
CALM3
chr19
46601074
46610782
+
RPL37
chr5
40825262
40835222
-
PLEKHG3
chr14
64704102
64750249
+
SMAD4
chr18
51028394
51085045
+
SNX5
chr20
17941597
17968980
-
PPP2R3B
chrX
333933
386955
-
SCMH1
chr1
41027200
41242154
-
LCK
chr1
32251239
32286165
+
SIK2
chr11
111602449
111730855
+
PPP2R1B
chr11
111726908
111766389
-
SNX2
chr5
122775079
122834543
+
KLHL23
chr2
169694488
169776989
+
RAB4B-EGLN2
chr19
40778242
40808418
+
WDR86
chr7
151375909
151410727
-
REPS1
chr6
138903493
138988261
-
PABPC3
chr13
25095868
25099254
+
PROCA1
chr17
28703197
28711854
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-185-5p
chr22
20033153
20033174
+
hsa-miR-423-5p
chr17
30117095
30117117
+
hsa-miR-1323
chr19
53671978
53671999
+
hsa-miR-548o-3p
chr20
38516607
38516628
+
circRNA targets:NA
lncRNA targets:NA
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.