Entry Detail


General Information

Database ID:exR0510818
RNA Name:ACAA1
RNA Type:mRNA
Chromosome:chr3
Starnd:-
Coordinate:
Start Site(bp):38103129End Site(bp):38137242
External Links:ENSG00000060971



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
NDUFS8
chr11
68030617
68036644
+
SYNGR2
chr17
78168558
78173527
+
ATXN7L2
chr1
109483479
109492804
+
EIF3B
chr7
2354086
2380745
+
MARCKSL1
chr1
32333839
32336233
-
COTL1
chr16
84565596
84618078
-
ZNF331
chr19
53519527
53580269
+
RPS3
chr11
75399515
75422280
+
ICMT
chr1
6221193
6235972
-
ZFHX3
chr16
72782885
73891871
-
TPP1
chr11
6612768
6619448
-
RPL37A
chr2
216498825
216579180
+
TIMP2
chr17
78852977
78925387
-
ST6GAL1
chr3
186930502
187078553
+
DCTN5
chr16
23641466
23677472
+
PTOV1
chr19
49850735
49860744
+
KCTD13
chr16
29905012
29926236
-
TRAP1
chr16
3651639
3717553
-
CEP295NL
chr17
78870910
78903217
-
RPL11
chr1
23691742
23696835
+
LMNB1
chr5
126776623
126837020
+
MRPS27
chr5
72219409
72320646
-
DDX3Y
chrY
12904108
12920478
+
NPNT
chr4
105894775
106004027
+
MTRNR2L12
chr3
96617188
96618236
-
LIN28A
chr1
26410817
26429728
+
MPRIP
chr17
17042545
17217679
+
HDAC1
chr1
32292083
32333635
+
ZBTB40
chr1
22428838
22531157
+
RPS4X
chrX
72255679
72277248
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-4449
chr4
52712720
52712741
+
circRNA targets:NA
lncRNA targets:NA
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.