Entry Detail


General Information

Database ID:exR0510852
RNA Name:ACO1
RNA Type:mRNA
Chromosome:chr9
Starnd:+
Coordinate:
Start Site(bp):32384603End Site(bp):32454769
External Links:ENSG00000122729



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
UBA52
chr19
18571730
18577550
+
SLC25A6
chrX
1386152
1392113
-
PCGF3
chr4
705748
770640
+
INSR
chr19
7112255
7294414
-
EEF2
chr19
3976056
3985463
-
UNG
chr12
109097574
109110992
+
STRN4
chr19
46719511
46746994
-
MIF
chr22
23894383
23895227
+
CRMP1
chr4
5748084
5893086
-
TOP2A
chr17
40388525
40417896
-
RAB3D
chr19
11322068
11346270
-
RPL17
chr18
49488453
49492523
-
RPL23
chr17
38847860
38853764
-
TMEM250
chr9
136114581
136118875
-
IGFBP5
chr2
216672105
216695549
-
XRCC5
chr2
216107464
216206303
+
RPL27
chr17
42998273
43002959
+
ZNF681
chr19
23739195
23758891
-
RLF
chr1
40161387
40240921
+
IMMT
chr2
86143932
86195770
-
ECD
chr10
73130155
73169055
-
PTPN11
chr12
112418351
112509913
+
TPT1
chr13
45333471
45341370
-
DAD1
chr14
22564907
22589224
-
AKAP1
chr17
57085092
57121346
+
CDCA7L
chr7
21900899
21945903
-
BID
chr22
17734138
17774770
-
WDR27
chr6
169457212
169702067
-
CCT7
chr2
73233420
73253021
+
CD274
chr9
5450503
5470566
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
OIP5-AS1
chr15
41283990
41309737
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.