Entry Detail


General Information

Database ID:exR0510854
RNA Name:ACOT1
RNA Type:mRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):73537143End Site(bp):73543796
External Links:ENSG00000184227



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABHD14B
chr3
51968510
51983409
-
ACAP2
chr3
195274745
195443044
-
ACOT2
chr14
73567620
73575658
+
ACOT4
chr14
73591706
73596496
+
ACOT6
chr14
73610945
73619888
+
B2M
chr15
44711487
44718877
+
FOXO3
chr6
108559835
108684774
+
ITPR3
chr6
33620365
33696574
+
MAPKAPK5
chr12
111842228
111902222
+
MUC4
chr3
195746765
195811973
-
PPIB
chr15
64155812
64163205
-
RAC2
chr22
37225270
37244448
-
RGS16
chr1
182598623
182604389
-
RPL13A
chr19
49487554
49492308
+
RPS20
chr8
56067295
56074581
-
TPM2
chr9
35681992
35690056
-
ZDHHC4
chr7
6577434
6589374
+
ZNF592
chr15
84748592
84806445
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC092296.2
chr19
36304564
36321274
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.