Entry Detail


General Information

Database ID:exR0510889
RNA Name:ACTA2
RNA Type:mRNA
Chromosome:chr10
Starnd:-
Coordinate:
Start Site(bp):88935074End Site(bp):88991339
External Links:ENSG00000107796



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ZNF516
chr18
76357682
76495242
-
HNRNPDL
chr4
82422564
82430408
-
RPS16
chr19
39433137
39435949
-
HLA-B
chr6
31269491
31357188
-
ATP5F1B
chr12
56638175
56645984
-
TMSB4X
chrX
12975110
12977227
+
HLA-A
chr6
29941260
29945884
+
POTEF
chr2
130073535
130129222
-
GCN1
chr12
120127202
120194715
-
HNRNPH3
chr10
68331174
68343191
+
TRAP1
chr16
3651639
3717553
-
ATP5PB
chr1
111448864
111462773
+
PWWP2B
chr10
132397168
132417859
+
PHF23
chr17
7235029
7239722
-
HLA-DMA
chr6
32948613
32969094
-
RPS8
chr1
44775251
44778779
+
PEX2
chr8
76980258
77001044
-
BAIAP2L1
chr7
98291650
98401090
-
CLUH
chr17
2689386
2712663
-
UQCRC1
chr3
48599002
48610976
-
CCT7
chr2
73233420
73253021
+
HLA-DQA1
chr6
32628179
32647062
+
ACTG1
chr17
81509971
81523847
-
CNBP
chr3
129169484
129183922
-
PTTG1
chr5
160421855
160428739
+
ATN1
chr12
6924463
6942321
+
DDIT4
chr10
72273924
72276036
+
POLN
chr4
2071918
2242121
-
RAB12
chr18
8609437
8639382
+
RARA
chr17
40309180
40357643
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC139149.1
chr17
81514047
81527776
+
AC013269.1
chr2
130530275
130537182
+
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.