Entry Detail


General Information

Database ID:exR0510892
RNA Name:ACTC1
RNA Type:mRNA
Chromosome:chr15
Starnd:-
Coordinate:
Start Site(bp):34790230End Site(bp):34795549
External Links:ENSG00000159251



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
SLC12A6
chr15
34229784
34338060
-
PRKDC
chr8
47773111
47960178
-
POTEI
chr2
130459455
130509707
-
VAT1
chr17
43014607
43025123
-
IL16
chr15
81159575
81314058
+
PCNA
chr20
5114953
5126626
-
FAM185A
chr7
102748971
102809225
+
RPS17
chr15
82536750
82540459
-
EDC3
chr15
74630558
74696292
-
TBC1D9B
chr5
179862066
179907859
-
ZBTB45
chr19
58513530
58538911
-
B2M
chr15
44711487
44718877
+
EID1
chr15
48878134
48880173
+
ENO2
chr12
6913745
6923698
+
UBQLN4
chr1
156035299
156053798
-
ATP1A1
chr1
116372668
116410261
+
AP1G1
chr16
71729000
71809201
-
SNRPB
chr20
2461634
2470853
-
RPL26
chr17
8377516
8383213
-
G6PD
chrX
154531391
154547572
-
CAND1
chr12
67269358
67319953
+
TPI1
chr12
6867119
6870948
+
AC245033.1
chr15
82536788
82573194
-
ACTR1A
chr10
102461881
102502712
-
CASC4
chr15
44288719
44415758
+
ACTA1
chr1
229431245
229434098
-
SORL1
chr11
121452314
121633763
+
JTB
chr1
153974269
153977674
-
VPS51
chr11
65089324
65111862
+
SERF2
chr15
43777087
43802589
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC019205.1
chr6
73263212
73301789
+
AC105339.2
chr15
82752884
82757208
+
AC139149.1
chr17
81514047
81527776
+
AC012379.1
chr15
48783190
48784121
+
AC135178.2
chr17
8318088
8318712
-
AL359924.1
chr1
237862175
237928321
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.