Entry Detail


General Information

Database ID:exR0510899
RNA Name:ACTN1
RNA Type:mRNA
Chromosome:chr14
Starnd:-
Coordinate:
Start Site(bp):68874143End Site(bp):68979440
External Links:ENSG00000072110



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
SLCO3A1
chr15
91853708
92172435
+
ATP5F1B
chr12
56638175
56645984
-
MT-CO2
chrMT
7586
8269
+
ZNF865
chr19
55605405
55617269
+
DPM2
chr9
127935099
127938484
-
G3BP1
chr5
151771045
151812785
+
ACTN3
chr11
66546395
66563334
+
VAT1
chr17
43014607
43025123
-
HMGN1
chr21
39342315
39349647
-
SUPT16H
chr14
21351476
21384019
-
PLPP3
chr1
56494761
56645301
-
ERG28
chr14
75649791
75660876
-
PKM
chr15
72199029
72231822
-
SPIN2B
chrX
57118551
57121546
-
NPC2
chr14
74476192
74494177
-
PFKL
chr21
44300051
44327376
+
FYN
chr6
111660332
111873452
-
FARP2
chr2
241356285
241494841
+
TRAF7
chr16
2155698
2178129
+
AC245033.1
chr15
82536788
82573194
-
SEC11A
chr15
84669538
84716460
-
HLA-B
chr6
31269491
31357188
-
DGCR8
chr22
20080232
20111877
+
CHTF8
chr16
69118010
69132578
-
ITFG2
chr12
2812622
2859791
+
POLL
chr10
101578882
101588270
-
POLB
chr8
42338454
42371808
+
ROCK1
chr18
20946906
21111813
-
CNOT1
chr16
58519951
58629885
-
PITPNA
chr17
1517718
1562792
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-367-3p
chr4
112647877
112647898
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC245033.4
chr15
82533175
82540008
-
BX284668.5
chr1
16887577
16889706
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.