Entry Detail


General Information

Database ID:exR0510905
RNA Name:ACTR2
RNA Type:mRNA
Chromosome:chr2
Starnd:+
Coordinate:
Start Site(bp):65227753End Site(bp):65271253
External Links:ENSG00000138071



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TBPL1
chr6
133952170
133990432
+
LEPROT
chr1
65420587
65436007
+
SHMT2
chr12
57229573
57234935
+
DDX10
chr11
108665069
108940927
+
VASH2
chr1
212950520
212992037
+
FUS
chr16
31180110
31194871
+
FAAP100
chr17
81539885
81553961
-
KIAA0355
chr19
34254552
34355571
+
WASF2
chr1
27404230
27490167
-
TUBA3D
chr2
131476119
131482934
+
UBA52
chr19
18571730
18577550
+
SURF6
chr9
133328776
133336188
-
AMOT
chrX
112774503
112840815
-
RBM47
chr4
40423267
40630875
-
TBC1D7
chr6
13266542
13328583
-
GLS
chr2
190880821
190965552
+
PRMT5
chr14
22920525
22929408
-
IGF2
chr11
2129112
2141238
-
GZF1
chr20
23362182
23373062
+
UCHL5
chr1
193012250
193060080
-
VTA1
chr6
142147162
142224685
+
MXI1
chr10
110207605
110287365
+
FRMD8
chr11
65386621
65413525
+
RTN3
chr11
63681446
63759891
+
KPNA1
chr3
122421902
122514945
-
AL035078.4
chr11
31812391
32104665
+
MTRNR2L12
chr3
96617188
96618236
-
RAC2
chr22
37225270
37244448
-
RBM8A
chr1
145917714
145927678
-
ATP9B
chr18
79069285
79378287
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC068831.7
chr15
91022766
91023200
+
AC138761.1
chr17
22266395
22288301
+
LINC01018
chr5
6582136
6600288
+
LINC01641
chr1
227393554
227431035
+
OIP5-AS1
chr15
41283990
41309737
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.