Entry Detail


General Information

Database ID:exR0510919
RNA Name:ACY1
RNA Type:mRNA
Chromosome:chr3
Starnd:+
Coordinate:
Start Site(bp):51983340End Site(bp):51989197
External Links:ENSG00000243989



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
INVS
chr9
100099243
100302175
+
PPP2R5E
chr14
63371364
63543377
-
SRSF1
chr17
58000919
58007346
-
ANP32A
chr15
68778535
68820897
-
KDELR2
chr7
6445953
6484190
-
OAS2
chr12
112978395
113011723
+
ILF3
chr19
10654261
10692417
+
SLC25A3
chr12
98593591
98606379
+
ABCG2
chr4
88090150
88231628
-
MAPK3
chr16
30114105
30123506
-
TUBA1B
chr12
49127782
49131397
-
NEDD8
chr14
24216857
24232367
-
ABHD14A-ACY1
chr3
51974706
51989183
+
LASP1
chr17
38869859
38921770
+
HERC1
chr15
63608618
63833948
-
LRIG3
chr12
58872149
58920522
-
TPI1
chr12
6867119
6870948
+
ZNF623
chr8
143636013
143656418
+
UBC
chr12
124911604
124917368
-
RPS3
chr11
75399515
75422280
+
RBM38
chr20
57391396
57409333
+
UCKL1
chr20
63939829
63956416
-
PPTC7
chr12
110533245
110583318
-
TRIM28
chr19
58544064
58550722
+
RPLP0
chr12
120196699
120201235
-
PABPN1
chr14
23321289
23326185
+
GANAB
chr11
62624826
62646726
-
PLAT
chr8
42174718
42207676
-
TMEM184B
chr22
38219291
38273010
-
GNL3
chr3
52681156
52694497
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-625-5p
chr14
65471116
65471136
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AD000090.1
chr19
35557956
35581954
+
DANCR
chr4
52712404
52720351
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.