Entry Detail


General Information

Database ID:exR0510926
RNA Name:ADAM10
RNA Type:mRNA
Chromosome:chr15
Starnd:-
Coordinate:
Start Site(bp):58588809End Site(bp):58749791
External Links:ENSG00000137845



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
RPS11
chr19
49496365
49499708
+
THUMPD3
chr3
9362971
9386791
+
ATXN3
chr14
92044496
92106621
-
NUDT21
chr16
56429133
56452199
-
MORF4L1
chr15
78810487
78898139
+
RPS24
chr10
78033760
78056813
+
SMARCC1
chr3
47585269
47782106
-
YY1
chr14
100238298
100282788
+
RB1CC1
chr8
52622458
52745843
-
SPATS2L
chr2
200305881
200482264
+
MAPK9
chr5
180233143
180292099
-
RFLNA
chr12
123973241
124316024
+
TCTN3
chr10
95663396
95694143
-
RPL13
chr16
89560657
89566828
+
MRPL30
chr2
99181152
99199561
+
METTL2B
chr7
128476729
128506602
+
MPZL1
chr1
167721192
167791919
+
OSBP
chr11
59574398
59615774
-
PBX1
chr1
164555584
164899296
+
TAB2
chr6
149218641
149411613
+
RBM42
chr19
35629030
35637686
+
WBP11
chr12
14784582
14803486
-
TMEM189
chr20
50118254
50153734
-
TRIM28
chr19
58544064
58550722
+
GNAI3
chr1
109548615
109600195
+
ANXA6
chr5
151100706
151157785
-
XRCC6
chr22
41621119
41664048
+
PGM3
chr6
83161150
83193936
-
ACTN4
chr19
38647649
38731589
+
E2F2
chr1
23506438
23531233
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-1248
chr3
186786675
186786701
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AL096870.2
chr14
24209646
24215987
-
AC068790.8
chr12
123973215
124088594
+
AL645465.1
chr1
244375100
244409592
-
FGD5-AS1
chr3
14920347
14948424
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.