Entry Detail


General Information

Database ID:exR0510930
RNA Name:ADAM17
RNA Type:mRNA
Chromosome:chr2
Starnd:-
Coordinate:
Start Site(bp):9488486End Site(bp):9556732
External Links:ENSG00000151694



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ITM2C
chr2
230864639
230879248
+
HUNK
chr21
31873020
32044633
+
TPGS2
chr18
36777647
36829216
-
MOCS3
chr20
50958818
50963929
+
ESCO2
chr8
27771949
27812640
+
COMMD1
chr2
61888724
62147247
+
TMX1
chr14
51240162
51257655
+
NACA
chr12
56712427
56731628
-
ELOVL5
chr6
53267398
53349179
-
KHDRBS1
chr1
32013868
32060850
+
PSMA2
chr7
42916861
42932185
-
PTMA
chr2
231706895
231713541
+
GATAD1
chr7
92447482
92460075
+
SLC30A9
chr4
41990502
42090461
+
SUGP2
chr19
18990888
19034023
-
CCT5
chr5
10249929
10266389
+
RNF44
chr5
176526712
176538025
-
ATP5MC3
chr2
175176258
175184607
-
G6PC3
chr17
44070735
44076344
+
ZSCAN30
chr18
35251058
35290245
-
MDN1
chr6
89642498
89819794
-
GSTP1
chr11
67583742
67586656
+
MARCKSL1
chr1
32333839
32336233
-
PSMD2
chr3
184299198
184309050
+
XPO6
chr16
28097979
28211920
-
EIF3A
chr10
119033670
119080823
-
AL136454.1
chr1
192716132
192716653
+
PIK3CA
chr3
179148114
179240093
+
COL11A2
chr6
33162681
33192499
-
ZNF24
chr18
35332227
35345482
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
BX284668.2
chr1
16870945
16883659
+
LINC01783
chr1
16533886
16536172
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.