Entry Detail


General Information

Database ID:exR0511030
RNA Name:AFAP1L2
RNA Type:mRNA
Chromosome:chr10
Starnd:-
Coordinate:
Start Site(bp):114294824End Site(bp):114404756
External Links:ENSG00000169129



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
EEF1A1
chr6
73515750
73523797
-
EHMT1
chr9
137618992
137870016
+
FDFT1
chr8
11795573
11839304
+
FTL
chr19
48965309
48966879
+
KCNC4
chr1
110211343
110283100
+
KHDRBS1
chr1
32013868
32060850
+
NUP37
chr12
102073103
102120120
-
RAB5B
chr12
55973913
55996683
+
RPLP1
chr15
69452814
69456205
+
SLC2A3
chr12
7919230
7936187
-
WTIP
chr19
34481758
34512304
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
ERICH6-AS1
chr3
150703564
150723005
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.