Entry Detail


General Information

Database ID:exR0511031
RNA Name:AFF1
RNA Type:mRNA
Chromosome:chr4
Starnd:+
Coordinate:
Start Site(bp):86935002End Site(bp):87141054
External Links:ENSG00000172493



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AP1G1
chr16
71729000
71809201
-
TMBIM6
chr12
49707725
49764934
+
UBALD2
chr17
76265348
76271298
+
KIF1C
chr17
4997950
5028401
+
ERAL1
chr17
28855010
28861061
+
HNRNPM
chr19
8444767
8489114
+
DUSP5
chr10
110497907
110511533
+
VPS13A
chr9
77177445
77421537
+
RAB5C
chr17
42124976
42155044
-
RAVER2
chr1
64745095
64833232
+
RSU1
chr10
16590611
16817463
-
DNAJC5
chr20
63895126
63936031
+
RHEB
chr7
151466012
151520120
-
TSR1
chr17
2322396
2336657
-
CHD8
chr14
21385194
21456126
-
UNC13D
chr17
75827225
75844717
-
MCM2
chr3
127598410
127622436
+
RANBP2
chr2
108719482
108785809
+
ACTG1
chr17
81509971
81523847
-
PRDX6
chr1
173477330
173488815
+
BAZ1B
chr7
73440406
73522293
-
ABI1
chr10
26746593
26861087
-
KRAS
chr12
25205246
25250936
-
STRBP
chr9
123109500
123268586
-
CC2D1A
chr19
13906201
13930879
+
COPS8
chr2
237085882
237100474
+
DEDD
chr1
161120974
161132688
-
SSRP1
chr11
57325986
57335892
-
CASP8
chr2
201233443
201287711
+
TMEM237
chr2
201620184
201643570
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC025181.2
chr5
32174471
32175272
+
MAPKAPK5-AS1
chr12
111839764
111842902
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.