Entry Detail


General Information

Database ID:exR0511033
RNA Name:AFF3
RNA Type:mRNA
Chromosome:chr2
Starnd:-
Coordinate:
Start Site(bp):99545419End Site(bp):100192428
External Links:ENSG00000144218



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC135050.2
chr16
31083439
31094956
-
ALG8
chr11
78100936
78139653
-
CCNF
chr16
2429394
2458854
+
CEP170
chr1
243124428
243255348
-
CERS5
chr12
50129289
50167533
-
FBXL19
chr16
30923055
30948783
+
FOXP2
chr7
114086327
114693772
+
GNB2
chr7
100673567
100679174
+
HDDC3
chr15
90929964
90935196
-
HMGA2
chr12
65824131
65966295
+
HS6ST1
chr2
128236716
128318868
-
INTS7
chr1
211940399
212035557
-
JRK
chr8
142657460
142681968
-
MECOM
chr3
169083499
169663775
-
NISCH
chr3
52455118
52493068
+
SIPA1L3
chr19
37907208
38208369
+
TMEM250
chr9
136114581
136118875
-
VKORC1
chr16
31090842
31095980
-
ZBED4
chr22
49853844
49890080
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-33a-5p
chr22
41900949
41900969
+
hsa-miR-520d-5p
chr19
53720111
53720130
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC026471.1
chr16
31456711
31459736
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.