Entry Detail


General Information

Database ID:exR0511064
RNA Name:AGRN
RNA Type:mRNA
Chromosome:chr1
Starnd:+
Coordinate:
Start Site(bp):1020120End Site(bp):1056118
External Links:ENSG00000188157



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABCA2
chr9
137007234
137028922
-
LDB1
chr10
102106489
102120368
-
PPP1R14B
chr11
64244479
64246943
-
SAE1
chr19
47113274
47210636
+
BTBD2
chr19
1985438
2034881
-
ARFGAP2
chr11
47164299
47177125
-
HAX1
chr1
154272589
154275875
+
GPR153
chr1
6247353
6261098
-
SHMT2
chr12
57229573
57234935
+
INPPL1
chr11
72223701
72239147
+
TSPAN4
chr11
842812
867116
+
ZCCHC14
chr16
87406246
87493024
-
CKAP5
chr11
46743048
46846308
-
POP7
chr7
100706121
100707486
+
PSMC5
chr17
63827152
63832026
+
VPS26A
chr10
69123512
69174412
+
AP002990.1
chr11
62559603
62591531
-
PAK6
chr15
40217428
40277487
+
ARFGEF1
chr8
67173511
67343781
-
TECR
chr19
14517085
14565980
+
TLN1
chr9
35696948
35732195
-
CHD2
chr15
92900189
93027996
+
TOE1
chr1
45340052
45343973
+
STK11
chr19
1177558
1228431
+
FGFRL1
chr4
1009936
1026898
+
CYB5R3
chr22
42617840
42649392
-
OTUD5
chrX
48922028
48958386
-
EAF1
chr3
15427598
15450635
+
EFTUD2
chr17
44849948
44899445
-
DERA
chr12
15911302
16037381
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-let-7a-5p
chr9
94175962
94175983
+
hsa-miR-184
chr15
79209840
79209861
+
hsa-miR-654-5p
chr14
101040234
101040255
+
hsa-miR-541-3p
chr14
101064548
101064569
+
hsa-miR-5100
chr10
42997630
42997651
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC002470.2
chr22
20979462
20998121
+
AC005332.6
chr17
68126666
68129586
+
AC079922.2
chr2
112641832
112645720
-
AC114271.1
chr19
10333436
10336248
+
AD000090.1
chr19
35557956
35581954
+
AL031963.3
chr6
3068045
3068894
-
AC079949.1
chr12
127142029
127146532
-
AL645608.6
chr1
904834
915976
+
AL662884.1
chr6
32184733
32185882
-
AP001107.5
chr11
66409158
66417137
+
BACH1-IT2
chr21
29370497
29373709
+
EPB41L4A-AS1
chr5
112160526
112164818
+
MIRLET7BHG
chr22
46053869
46113928
+
NOP14-AS1
chr4
2934882
2961738
+
NORAD
chr20
36045618
36051018
-
SNHG3
chr1
28505980
28510892
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.