Entry Detail


General Information

Database ID:exR0511101
RNA Name:AKAP1
RNA Type:mRNA
Chromosome:chr17
Starnd:+
Coordinate:
Start Site(bp):57085092End Site(bp):57121346
External Links:ENSG00000121057



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
LRCH3
chr3
197791226
197888436
+
TP53I11
chr11
44885903
44951306
-
UNKL
chr16
1363205
1414751
-
NUP210
chr3
13316235
13420322
-
CUEDC2
chr10
102423245
102432584
-
TAF6
chr7
100107070
100119841
-
MT-ND4
chrMT
10760
12137
+
YME1L1
chr10
27110112
27155266
-
NOP56
chr20
2652593
2658393
+
TAOK2
chr16
29973868
29992261
+
LIN28A
chr1
26410817
26429728
+
TBC1D9B
chr5
179862066
179907859
-
PLCG2
chr16
81739097
81962685
+
CYBRD1
chr2
171522247
171558129
+
ABCE1
chr4
145098288
145129524
+
NAP1L4
chr11
2944431
2992377
-
CC2D1B
chr1
52345723
52366193
-
WASF2
chr1
27404230
27490167
-
TMEM41A
chr3
185476496
185499057
-
NAPA
chr19
47487637
47515091
-
TPRG1L
chr1
3625015
3630127
+
TOP2A
chr17
40388525
40417896
-
RAN
chr12
130872037
130877678
+
SENP3-EIF4A1
chr17
7563287
7578715
+
TSC22D1
chr13
44432143
44577147
-
SLC2A11
chr22
23856703
23886309
+
FKRP
chr19
46746046
46776988
+
UBL5
chr19
9827892
9830115
+
LMAN2
chr5
177331567
177351668
-
POLL
chr10
101578882
101588270
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-1197
chr14
101025620
101025640
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005618.1
chr5
141326210
141329357
+
AC016876.2
chr17
7581964
7584086
-
AC008738.1
chr19
33178056
33178651
+
ERVK13-1
chr16
2660348
2682379
-
LINC00458
chr13
54115783
54142319
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.