Entry Detail


General Information

Database ID:exR0511111
RNA Name:AKAP8
RNA Type:mRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):15353385End Site(bp):15379798
External Links:ENSG00000105127



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ANAPC7
chr12
110372900
110403730
-
SHQ1
chr3
72749277
72861914
-
ZNF500
chr16
4748239
4767624
-
UBN1
chr16
4846665
4882401
+
CALR
chr19
12938578
12944489
+
ICE2
chr15
60419609
60479160
-
L1TD1
chr1
62194849
62212328
+
TRIP12
chr2
229763838
229923239
-
ZNF43
chr19
21804949
21852125
-
GMPS
chr3
155870650
155944020
+
ABCC1
chr16
15949577
16143074
+
RPL36A-HNRNPH2
chrX
101391011
101412297
+
BAMBI
chr10
28677510
28682932
+
NACA2
chr17
61590421
61591219
-
ZZEF1
chr17
4004445
4143030
-
PPP1R12C
chr19
55090914
55117637
-
TLE3
chr15
70047790
70098176
-
NCL
chr2
231453531
231483641
-
DCAF10
chr9
37800554
37867666
+
MIXL1
chr1
226223618
226227054
+
NAT10
chr11
34105617
34147670
+
ALDOA
chr16
30064164
30070457
+
MON1B
chr16
77190835
77202398
+
TIMMDC1
chr3
119498547
119525090
+
SH3PXD2A
chr10
103594027
103855543
-
ATF6B
chr6
32115264
32128253
-
CDK7
chr5
69234795
69277430
+
RIPOR1
chr16
67518418
67546788
+
NPC2
chr14
74476192
74494177
-
CACNG6
chr19
53992288
54012669
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AL355075.4
chr14
20343048
20343685
-
LINC01248
chr2
5602505
5691488
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.