Entry Detail


General Information

Database ID:exR0511112
RNA Name:AKAP8L
RNA Type:mRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):15380050End Site(bp):15419141
External Links:ENSG00000011243



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AL357673.1
chr1
54132686
54200073
-
KRT8
chr12
52897187
52949954
-
C6orf136
chr6
30647039
30653210
+
NCKAP1L
chr12
54497752
54548243
+
OS9
chr12
57693955
57721557
+
STX12
chr1
27773219
27824443
+
MBD3
chr19
1573596
1592865
-
RPN1
chr3
128619969
128681075
-
PTP4A1
chr6
63521746
63583436
+
ACTN4
chr19
38647649
38731589
+
CENPH
chr5
69189574
69210357
+
RPL13
chr16
89560657
89566828
+
PTMA
chr2
231706895
231713541
+
MLST8
chr16
2204248
2209453
+
FNTA
chr8
43034194
43085788
+
MCM2
chr3
127598410
127622436
+
GRB2
chr17
75318076
75405709
-
CPSF1
chr8
144393229
144409335
-
DBN1
chr5
177456608
177474401
-
EIF3A
chr10
119033670
119080823
-
RPL13A
chr19
49487554
49492308
+
GALNT2
chr1
230057990
230282122
+
TPT1
chr13
45333471
45341370
-
NOMO1
chr16
14833721
14896157
+
NAA30
chr14
57390544
57415906
+
NDUFB8
chr10
100523740
100530000
-
RPL37A
chr2
216498825
216579180
+
STK25
chr2
241492670
241509730
-
LIN28A
chr1
26410817
26429728
+
APBA3
chr19
3750772
3761692
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AL021368.4
chr6
57919912
57961382
-
MALAT1
chr11
65497688
65506516
+
RMRP
chr9
35657751
35658018
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.