Entry Detail


General Information

Database ID:exR0514633
RNA Name:EIF4A1
RNA Type:mRNA
Chromosome:chr17
Starnd:+
Coordinate:
Start Site(bp):7572706End Site(bp):7579006
External Links:ENSG00000161960



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABCA2
chr9
137007234
137028922
-
ABCB8
chr7
151028422
151047782
+
ABRACL
chr6
139028745
139043302
+
AC004080.3
chr7
27163535
27180013
-
AC004922.1
chr7
99325879
99394653
+
AC004997.1
chr22
30285238
30299482
-
AC010463.1
chr19
17267418
17282966
+
AC011511.4
chr19
10315471
10320678
-
AC026464.4
chr16
69299682
69322700
+
AC048338.1
chr12
122207779
122266423
-
AC073896.1
chr12
56285916
56316059
-
AC092143.1
chr16
89919165
89936092
+
AC245033.1
chr15
82536788
82573194
-
ACSS3
chr12
80936414
81261210
+
ACTB
chr7
5527148
5563784
-
ACTG1
chr17
81509971
81523847
-
ACTN4
chr19
38647649
38731589
+
ADPGK
chr15
72751369
72785846
-
AFAP1
chr4
7758714
7939926
-
AGPAT1
chr6
32168212
32178096
-
AHCY
chr20
34280268
34311802
-
AK1
chr9
127866486
127877675
-
AKAP1
chr17
57085092
57121346
+
AL139300.1
chr14
103562962
103685924
+
ALDH18A1
chr10
95605941
95656711
-
ALDH7A1
chr5
126531200
126595362
-
ALDOA
chr16
30064164
30070457
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-28-5p
chr3
188688794
188688815
+
hsa-miR-129-5p
chr7
128207876
128207896
+
hsa-miR-330-5p
chr19
45639049
45639070
-
hsa-miR-1294
chr5
154347153
154347174
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC006064.5
chr12
6510275
6510522
+
AC007952.4
chr17
19112000
19112636
-
AC010542.4
chr16
66549280
66551189
+
AC016876.2
chr17
7581964
7584086
-
AC064802.1
chr8
114282067
114295839
+
AC132217.1
chr11
2129121
2129964
-
AC135050.5
chr16
31118078
31118747
+
AC245033.4
chr15
82533175
82540008
-
AD000090.1
chr19
35557956
35581954
+
AL008721.2
chr22
25476218
25479971
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.