Entry Detail


General Information

Database ID:exR0514636
RNA Name:EIF4B
RNA Type:mRNA
Chromosome:chr12
Starnd:+
Coordinate:
Start Site(bp):53006158End Site(bp):53042209
External Links:ENSG00000063046



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABLIM1
chr10
114431113
114768061
-
AC008763.3
chr19
7678501
7682854
+
AC010422.3
chr19
12643831
12648397
-
AC011462.1
chr19
41350853
41425001
+
AC058822.1
chr4
53377839
54295272
+
AC073508.2
chr17
40627356
40665141
-
AC093525.1
chr16
2513965
2527955
+
AC124312.1
chr15
24955034
25000276
+
AC245033.1
chr15
82536788
82573194
-
ACADVL
chr17
7217125
7225266
+
ACOT8
chr20
45841721
45857405
-
ACSF2
chr17
50426158
50474845
+
ACTB
chr7
5527148
5563784
-
ACTG1
chr17
81509971
81523847
-
ACVR1
chr2
157736444
157876330
-
ADAL
chr15
43330657
43354555
+
ADAR
chr1
154582057
154628013
-
ADIPOR2
chr12
1688574
1788674
+
ADORA2A
chr22
24417879
24442357
+
AEN
chr15
88621337
88632281
+
AGBL5
chr2
27042364
27070622
+
AHCY
chr20
34280268
34311802
-
AIG1
chr6
143060496
143341058
+
AIMP1
chr4
106315544
106349456
+
AKNA
chr9
114334156
114394405
-
AL121594.1
chr14
35122549
35317474
+
AL139011.2
chr1
160216800
160285130
-
ALDOA
chr16
30064164
30070457
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-3680-5p
chr16
21506101
21506122
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC018647.2
chr7
35695214
35699413
+
AC023509.1
chr12
53441741
53467528
+
AC245033.4
chr15
82533175
82540008
-
AD000090.1
chr19
35557956
35581954
+
AL022311.1
chr22
37876148
37895563
+
AL118506.1
chr20
63861212
63864293
-
AL121832.3
chr20
62402236
62405935
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.