Entry Detail


General Information

Database ID:exR0514934
RNA Name:FADS2
RNA Type:mRNA
Chromosome:chr11
Starnd:+
Coordinate:
Start Site(bp):61792980End Site(bp):61867354
External Links:ENSG00000134824



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABCF2
chr7
151207837
151227166
-
ABRAXAS1
chr4
83459517
83523348
-
AC010422.3
chr19
12643831
12648397
-
AC010463.1
chr19
17267418
17282966
+
AC013394.1
chr15
92883413
92949230
+
AC067968.1
chr19
44025354
44087318
+
AC245033.1
chr15
82536788
82573194
-
ACSL1
chr4
184755595
184826818
-
ACTB
chr7
5527148
5563784
-
ACTG1
chr17
81509971
81523847
-
ADCY6
chr12
48766194
48789037
-
AEN
chr15
88621337
88632281
+
AGA
chr4
177430774
177442437
-
AIFM1
chrX
130129362
130165887
-
AKAP8L
chr19
15380050
15419141
-
AKT2
chr19
40230317
40285536
-
AL121594.1
chr14
35122549
35317474
+
AL133352.1
chr10
100505628
100529881
-
AL365205.1
chr6
41780349
41790141
+
ALDOA
chr16
30064164
30070457
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-432-5p
chr14
100884496
100884518
+
hsa-miR-1321
chrX
85835832
85835849
+
hsa-miR-4485-3p
chr11
10508277
10508296
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004224.2
chr16
3458071
3515564
+
AC023509.1
chr12
53441741
53467528
+
AC245033.4
chr15
82533175
82540008
-
AD000090.1
chr19
35557956
35581954
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.