Entry Detail


General Information

Database ID:exR0717381
RNA Name:NONO
RNA Type:mRNA
Chromosome:chrX
Starnd:+
Coordinate:
Start Site(bp):71283192End Site(bp):71301168
External Links:ENSG00000147140



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABL1
chr9
130713016
130887675
+
AC006064.6
chr12
6556886
6607367
-
AC010422.3
chr19
12643831
12648397
-
AC011455.2
chr19
38915404
38949855
-
AC078927.1
chr12
66123917
66169985
-
ACADVL
chr17
7217125
7225266
+
ACER3
chr11
76860867
77026797
+
ACSS3
chr12
80936414
81261210
+
ACTR6
chr12
100199122
100241865
+
AGAP4
chr10
45825594
45853875
-
AHCY
chr20
34280268
34311802
-
AIF1L
chr9
131096476
131123152
+
AKT2
chr19
40230317
40285536
-
AL049779.1
chr14
67659820
67690367
-
AL133352.1
chr10
100505628
100529881
-
ALDH1B1
chr9
38392702
38398661
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-379-5p
chr14
101022071
101022091
+
hsa-miR-338-3p
chr17
81125887
81125908
-
hsa-miR-650
chr22
22822791
22822811
+
hsa-miR-941
chr20
63919551
63919573
+
hsa-miR-3654
chr7
133034860
133034878
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC023509.1
chr12
53441741
53467528
+
AC092490.1
chr12
8788253
8795789
+
AC132217.1
chr11
2129121
2129964
-
AD000090.1
chr19
35557956
35581954
+
AL022311.1
chr22
37876148
37895563
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.