Entry Detail


General Information

Database ID:exR0718414
RNA Name:PFN1
RNA Type:mRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):4945652End Site(bp):4949061
External Links:ENSG00000108518



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AFAP1
chr4
7758714
7939926
-
ADGRA3
chr4
22345071
22516066
-
AGFG1
chr2
227472152
227561214
+
AJM1
chr9
136844415
136848801
+
ADD1
chr4
2843857
2930076
+
AC099489.1
chr16
11359845
11527245
-
AL139011.2
chr1
160216800
160285130
-
ACOX2
chr3
58505136
58537283
-
AC139530.2
chr17
81703371
81720539
+
AC104109.3
chr5
134167170
134226071
-
AC099811.2
chr17
42119674
42154916
-
AC092143.1
chr16
89919165
89936092
+
ALDOA
chr16
30064164
30070457
+
ACSS2
chr20
34872146
34927962
+
ABCD4
chr14
74285269
74303055
-
AGA
chr4
177430774
177442437
-
AC073508.2
chr17
40627356
40665141
-
AIFM1
chrX
130129362
130165887
-
AL121594.1
chr14
35122549
35317474
+
AC005258.1
chr19
2269525
2341172
+
AGRN
chr1
1020120
1056118
+
AGPAT5
chr8
6708642
6761503
+
ABCG2
chr4
88090150
88231628
-
ACTA1
chr1
229431245
229434098
-
ADAM10
chr15
58588809
58749791
-
AGPAT1
chr6
32168212
32178096
-
AHCY
chr20
34280268
34311802
-
ACTB
chr7
5527148
5563784
-
AC004922.1
chr7
99325879
99394653
+
AC008763.3
chr19
7678501
7682854
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-320a-3p
chr8
22244975
22244996
-
hsa-miR-330-3p
chr19
45639009
45639031
-
hsa-miR-320b
chr1
224257049
224257070
-
hsa-miR-320c
chr18
24321716
24321735
+
hsa-miR-320d
chr13
40727828
40727846
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004687.1
chr17
58330884
58332508
-
AC016876.2
chr17
7581964
7584086
-
AC020663.1
chr16
4730115
4752565
-
AC022031.2
chr18
55589904
55839184
+
AC023509.1
chr12
53441741
53467528
+
AC026362.1
chr12
122975320
122982907
+
AC060780.1
chr17
43148368
43171037
-
AC109460.3
chr16
28974804
28990775
+
AD000090.1
chr19
35557956
35581954
+
AL022311.1
chr22
37876148
37895563
+
AL023653.1
chrX
129794994
129796963
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.