Entry Detail


General Information

Database ID:exR0718653
RNA Name:PLCG2
RNA Type:mRNA
Chromosome:chr16
Starnd:+
Coordinate:
Start Site(bp):81739097End Site(bp):81962685
External Links:ENSG00000197943



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC000093.1
chr22
19717220
19724772
+
AC005943.1
chr19
1578339
1605445
-
AC009133.6
chr16
29812261
29820092
+
AC091167.2
chr15
90249556
90272208
+
AC137834.1
chr12
57249609
57296484
-
AC138811.2
chr16
18788063
18801519
-
AC245033.1
chr15
82536788
82573194
-
ACTB
chr7
5527148
5563784
-
ADCY9
chr16
3953387
4116442
-
AGO1
chr1
35869808
35930532
+
AHCY
chr20
34280268
34311802
-
AKAP1
chr17
57085092
57121346
+
AL365205.1
chr6
41780349
41790141
+
ALDH1A2
chr15
57953424
58497866
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-6506-3p
chr16
15611031
15611052
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC007952.4
chr17
19112000
19112636
-
AC067930.1
chr8
143579636
143580670
+
AC067930.4
chr8
143573490
143577397
+
AC091564.7
chr11
6610883
6616594
-
AC099524.1
chr16
81738248
81767868
+
AC109460.3
chr16
28974804
28990775
+
AD000090.1
chr19
35557956
35581954
+
AL096870.2
chr14
24209646
24215987
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.