Entry Detail


General Information

Database ID:exR0718693
RNA Name:PLEKHM1
RNA Type:mRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):45435900End Site(bp):45490749
External Links:ENSG00000225190



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ADRM1
chr20
62302093
62308862
+
AGO1
chr1
35869808
35930532
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-17-5p
chr13
91350618
91350640
+
hsa-miR-20a-5p
chr13
91351072
91351094
+
hsa-miR-24-3p
chr9
95086064
95086085
+
hsa-miR-93-5p
chr7
100093815
100093837
-
hsa-miR-106a-5p
chrX
134170244
134170266
-
hsa-miR-145-5p
chr5
149430661
149430683
+
hsa-miR-106b-5p
chr7
100094043
100094063
-
hsa-miR-302a-3p
chr4
112648186
112648208
-
hsa-miR-373-3p
chr19
53788748
53788770
+
hsa-miR-20b-5p
chrX
134169850
134169872
-
hsa-miR-512-3p
chr19
53666729
53666750
+
hsa-miR-520d-3p
chr19
53720149
53720170
+
hsa-miR-1323
chr19
53671978
53671999
+
hsa-miR-302e
chr11
7234771
7234787
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC012236.1
chr15
31221999
31230838
-
AC083843.3
chr8
134792020
134798272
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.