Entry Detail


General Information

Database ID:exR0718726
RNA Name:PLXNA1
RNA Type:mRNA
Chromosome:chr3
Starnd:+
Coordinate:
Start Site(bp):126988594End Site(bp):127037392
External Links:ENSG00000114554



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AAMP
chr2
218264123
218270257
-
AATF
chr17
36948954
37056871
+
ABCA2
chr9
137007234
137028922
-
ABHD4
chr14
22598237
22613215
+
ACAD10
chr12
111686056
111757107
+
ADAM11
chr17
44758988
44781846
+
ADAM9
chr8
38996869
39105261
+
ADD1
chr4
2843857
2930076
+
AGBL5
chr2
27042364
27070622
+
AGO2
chr8
140520156
140635633
-
AL139011.2
chr1
160216800
160285130
-
AL162417.1
chr9
133098121
133163914
-
AL513165.2
chr9
37512547
37592469
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-96-5p
chr7
129774739
129774761
-
hsa-miR-7-5p
chr19
4770700
4770723
+
hsa-miR-182-5p
chr7
129770447
129770470
-
hsa-miR-205-5p
chr1
209432166
209432187
+
hsa-miR-185-5p
chr22
20033153
20033174
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC002470.2
chr22
20979462
20998121
+
AC012531.1
chr12
54019910
54022589
+
AC016586.1
chr19
4061615
4062749
-
AC022007.1
chr3
10004048
10011209
-
AC026740.1
chr5
675826
676616
+
AL132780.1
chr14
22929607
22956374
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.