Entry Detail


General Information

Database ID:exR0720180
RNA Name:RTN4
RNA Type:mRNA
Chromosome:chr2
Starnd:-
Coordinate:
Start Site(bp):54972187End Site(bp):55112621
External Links:ENSG00000115310



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AAGAB
chr15
67200667
67255195
-
ABLIM1
chr10
114431113
114768061
-
ACAT2
chr6
159762045
159779112
+
ACLY
chr17
41866917
41930542
-
ACTG1
chr17
81509971
81523847
-
ADCY2
chr5
7396138
7830081
+
AKR7A2
chr1
19303965
19312146
-
AL133352.1
chr10
100505628
100529881
-
AL136454.1
chr1
192716132
192716653
+
AL136531.2
chr20
1317571
1393096
-
AL139011.2
chr1
160216800
160285130
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-148a-3p
chr7
25949922
25949943
-
hsa-miR-130a-3p
chr11
57641252
57641273
+
hsa-miR-301a-3p
chr17
59151149
59151171
-
hsa-miR-130b-3p
chr22
21653354
21653375
+
hsa-miR-454-3p
chr17
59137787
59137809
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC018521.1
chr17
47945424
47981736
+
AC026362.1
chr12
122975320
122982907
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.