Entry Detail


General Information

Database ID:exR0720417
RNA Name:SEC61A1
RNA Type:mRNA
Chromosome:chr3
Starnd:+
Coordinate:
Start Site(bp):128051641End Site(bp):128071683
External Links:ENSG00000058262



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC006064.6
chr12
6556886
6607367
-
AC023055.1
chr12
55757275
55827546
-
AC093525.2
chr16
2496032
2520218
+
ACIN1
chr14
23058564
23095614
-
ACTB
chr7
5527148
5563784
-
ACTR3
chr2
113890063
113962596
+
ADH5
chr4
99070978
99088801
-
ADRM1
chr20
62302093
62308862
+
AL139011.2
chr1
160216800
160285130
-
ALDOA
chr16
30064164
30070457
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-16-5p
chr3
160404754
160404775
+
hsa-miR-103a-3p
chr5
168560904
168560926
-
hsa-miR-107
chr10
89592756
89592778
-
hsa-miR-34a-5p
chr1
9151735
9151756
-
hsa-miR-214-3p
chr1
172138816
172138837
-
hsa-miR-34c-5p
chr11
111513451
111513473
+
hsa-miR-449b-5p
chr5
55170706
55170727
-
hsa-miR-589-5p
chr7
5495873
5495894
-
hsa-miR-3136-3p
chr3
69048966
69048987
-
hsa-miR-4700-5p
chr12
120723202
120723223
+
hsa-miR-4700-3p
chr12
120723233
120723258
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC016876.2
chr17
7581964
7584086
-
AC020928.2
chr19
36773712
36775908
-
AC023908.2
chr15
39770559
39801333
-
AL049796.1
chr1
93847174
93848939
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.