Entry Detail


General Information

Database ID:exR0721056
RNA Name:SMAD3
RNA Type:mRNA
Chromosome:chr15
Starnd:+
Coordinate:
Start Site(bp):67063763End Site(bp):67195169
External Links:ENSG00000166949



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC022384.1
chr3
10249372
10285796
+
ACP1
chr2
264140
278283
+
ACTB
chr7
5527148
5563784
-
ACTG1
chr17
81509971
81523847
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-31-5p
chr9
21512158
21512178
-
hsa-miR-122-5p
chr18
58451088
58451109
+
hsa-miR-185-5p
chr22
20033153
20033174
+
hsa-miR-663a
chr20
26208243
26208264
-
hsa-miR-654-5p
chr14
101040234
101040255
+
hsa-miR-671-5p
chr7
151238449
151238471
+
hsa-miR-330-5p
chr19
45639049
45639070
-
hsa-miR-744-5p
chr17
12081909
12081930
+
hsa-miR-1321
chrX
85835832
85835849
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC002470.2
chr22
20979462
20998121
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.