Entry Detail


General Information

Database ID:exR0721209
RNA Name:SON
RNA Type:mRNA
Chromosome:chr21
Starnd:+
Coordinate:
Start Site(bp):33543038End Site(bp):33577481
External Links:ENSG00000159140



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACACA
chr17
37084992
37406836
-
ACTB
chr7
5527148
5563784
-
ACTG1
chr17
81509971
81523847
-
ADAMTS1
chr21
26835755
26845409
-
ADNP2
chr18
80109262
80147523
+
ADSL
chr22
40346500
40390463
+
AFDN
chr6
167826922
167972023
+
AHCY
chr20
34280268
34311802
-
AIFM1
chrX
130129362
130165887
-
AKAP8L
chr19
15380050
15419141
-
AL022238.4
chr22
40346529
40410054
+
AL136454.1
chr1
192716132
192716653
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-143-3p
chr5
149428978
149428998
+
hsa-miR-6501-5p
chr21
33550664
33550685
+
hsa-miR-6501-3p
chr21
33550705
33550727
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC051619.7
chr15
45200325
45200632
-
AC105036.3
chr15
75527150
75601205
-
AC132217.1
chr11
2129121
2129964
-
AL021368.3
chr6
57855891
57856468
-
AL135999.1
chr14
23561097
23568073
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.