Entry Detail


General Information

Database ID:exR0721389
RNA Name:SREBF2
RNA Type:mRNA
Chromosome:chr22
Starnd:+
Coordinate:
Start Site(bp):41833079End Site(bp):41907307
External Links:ENSG00000198911



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AATF
chr17
36948954
37056871
+
ABCG2
chr4
88090150
88231628
-
AC005258.1
chr19
2269525
2341172
+
AC010422.3
chr19
12643831
12648397
-
AC015813.2
chr17
57989038
58007246
-
AC087289.3
chr17
75898645
75930129
-
AC118549.1
chr1
77562416
77683419
-
AC245033.1
chr15
82536788
82573194
-
ACLY
chr17
41866917
41930542
-
ACO2
chr22
41469117
41528989
+
ACSS3
chr12
80936414
81261210
+
ACTB
chr7
5527148
5563784
-
ACTN1
chr14
68874143
68979440
-
ADD2
chr2
70607618
70768225
-
ADGRG6
chr6
142301854
142446266
+
ADRM1
chr20
62302093
62308862
+
AFDN
chr6
167826922
167972023
+
AGO2
chr8
140520156
140635633
-
AKIRIN1
chr1
38991276
39006059
+
AKIRIN2
chr6
87674860
87702233
-
AL645941.2
chr6
32937364
32953122
-
ALDOA
chr16
30064164
30070457
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-185-5p
chr22
20033153
20033174
+
hsa-miR-625-5p
chr14
65471116
65471136
+
hsa-miR-650
chr22
22822791
22822811
+
hsa-miR-423-5p
chr17
30117095
30117117
+
hsa-miR-33a-3p
chr22
41900989
41901010
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC007952.4
chr17
19112000
19112636
-
AC026362.1
chr12
122975320
122982907
+
AC064807.1
chr8
51899268
51949874
+
AC078846.1
chr7
129604548
129611630
-
AC106864.1
chr4
112693047
112706810
-
AC132217.1
chr11
2129121
2129964
-
AC135048.1
chr16
30948386
30956511
+
AC138035.2
chr5
181329241
181342213
+
AC245033.4
chr15
82533175
82540008
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.