Entry Detail


General Information

Database ID:exR0721538
RNA Name:STK4
RNA Type:mRNA
Chromosome:chr20
Starnd:+
Coordinate:
Start Site(bp):44966479End Site(bp):45080021
External Links:ENSG00000101109



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABCF2
chr7
151207837
151227166
-
AC245033.1
chr15
82536788
82573194
-
AGPAT1
chr6
32168212
32178096
-
AGTRAP
chr1
11736084
11754802
+
AKR1B1
chr7
134442356
134459284
-
AKT3
chr1
243488233
243851079
-
ALDH9A1
chr1
165662216
165698863
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-let-7a-5p
chr9
94175962
94175983
+
hsa-miR-24-3p
chr9
95086064
95086085
+
hsa-miR-122-5p
chr18
58451088
58451109
+
hsa-miR-130a-3p
chr11
57641252
57641273
+
hsa-miR-135a-5p
chr12
97563834
97563856
+
hsa-miR-138-5p
chr16
56858527
56858549
+
hsa-miR-130b-3p
chr22
21653354
21653375
+
hsa-miR-362-5p
chrX
50008968
50008991
+
hsa-miR-135b-5p
chr1
205448361
205448383
-
hsa-miR-1224-5p
chr3
184241405
184241423
+
hsa-miR-1276
chr15
85770548
85770567
-
hsa-let-7c-5p
chr21
16539838
16539859
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC016876.2
chr17
7581964
7584086
-
AC087190.3
chr16
9104848
9113181
+
AC245033.4
chr15
82533175
82540008
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.