Entry Detail


General Information

Database ID:exR0722098
RNA Name:TLE3
RNA Type:mRNA
Chromosome:chr15
Starnd:-
Coordinate:
Start Site(bp):70047790End Site(bp):70098176
External Links:ENSG00000140332



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC006064.6
chr12
6556886
6607367
-
AC010422.3
chr19
12643831
12648397
-
AC011448.1
chr19
19516227
19536076
+
ACACA
chr17
37084992
37406836
-
ACOT7
chr1
6264269
6394391
-
ACTB
chr7
5527148
5563784
-
ACTG1
chr17
81509971
81523847
-
ADAM11
chr17
44758988
44781846
+
ADGRA3
chr4
22345071
22516066
-
ADIPOR1
chr1
202940826
202958572
-
AKAP8
chr19
15353385
15379798
-
ALDOA
chr16
30064164
30070457
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-185-5p
chr22
20033153
20033174
+
hsa-miR-423-5p
chr17
30117095
30117117
+
hsa-miR-1179
chr15
88608121
88608141
+
hsa-miR-1294
chr5
154347153
154347174
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC008738.5
chr19
33301279
33301940
+
AC008750.2
chr19
51415724
51417425
+
AC067930.1
chr8
143579636
143580670
+
AC245014.3
chr1
145281116
145281462
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.