exRNAdisease

Entry Detail

---



General Information

Database ID: exR0722439 RNA Name: TNRC6B RNA Type: mRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 40044817 End Site(bp): 40335808 External Links: ENSG00000100354

Disease Information

Disease Name: Lactation Disease Category: Other Diseases MeSH ID: D007774 Type: Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena Alias: Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations

Expression Detail

GEO ID: GSE36936 Description: Gene Expression in the Human Mammary Epithelium during Initiation of Lactation. Experimental Design: Time Series Case Disease Type: Lactation Case Disease SubType: NA Case Sample: Day 42 post delivery Control Sample: 6h post delivery Number of Case: 7 Number of Control: 7 Number of Samples: 14

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.6 chr16 29812261 29820092 + ADCY6 chr12 48766194 48789037 - AHI1 chr6 135283532 135497765 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-let-7a-5p chr9 94175962 94175983 + hsa-let-7b-5p chr22 46113691 46113712 + hsa-let-7e-5p chr19 51692793 51692814 + hsa-miR-129-5p chr7 128207876 128207896 + hsa-miR-147a chr9 120244985 120245004 - hsa-miR-34a-5p chr1 9151735 9151756 - hsa-let-7g-5p chr3 52268336 52268357 - hsa-let-7i-5p chr12 62603691 62603712 + hsa-miR-140-5p chr16 69933103 69933124 + hsa-miR-142-3p chr17 58331245 58331267 - hsa-miR-185-5p chr22 20033153 20033174 + hsa-miR-206 chr6 52144401 52144422 + hsa-miR-200a-3p chr1 1167916 1167937 + hsa-miR-34c-5p chr11 111513451 111513473 + hsa-miR-449a chr5 55170586 55170607 - hsa-miR-613 chr12 12764709 12764728 + hsa-miR-449b-5p chr5 55170706 55170727 - hsa-miR-501-3p chrX 50009772 50009793 + hsa-miR-502-3p chrX 50014649 50014670 + hsa-miR-616-3p chr12 57519183 57519204 - hsa-miR-1286 chr22 20249145 20249165 - hsa-miR-1321 chrX 85835832 85835849 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 22649065 Title: Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans Author: Mohammad MA, Hadsell DL, Haymond MW. Journal: Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76. Description: We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.