exRNAdisease

Entry Detail

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General Information

Database ID: exR0722446 RNA Name: TOB2 RNA Type: mRNA Chromosome: chr22 Starnd: - Coordinate: Start Site(bp): 41433494 End Site(bp): 41446801 External Links: ENSG00000183864

Disease Information

Disease Name: Lactation Disease Category: Other Diseases MeSH ID: D007774 Type: Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena Alias: Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations

Expression Detail

GEO ID: GSE36936 Description: Gene Expression in the Human Mammary Epithelium during Initiation of Lactation. Experimental Design: Time Series Case Disease Type: Lactation Case Disease SubType: NA Case Sample: Day 42 post delivery Control Sample: 6h post delivery Number of Case: 7 Number of Control: 7 Number of Samples: 14

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABL1 chr9 130713016 130887675 + AC004922.1 chr7 99325879 99394653 + AC008878.3 chr19 7382834 7470241 + ACBD6 chr1 180269653 180502954 - ADGRA3 chr4 22345071 22516066 - AHCY chr20 34280268 34311802 - AKAP1 chr17 57085092 57121346 + AL136295.4 chr14 24180395 24190416 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-16-5p chr3 160404754 160404775 + hsa-miR-23a-3p chr19 13836595 13836615 - hsa-miR-103a-3p chr5 168560904 168560926 - hsa-miR-107 chr10 89592756 89592778 - hsa-miR-34a-5p chr1 9151735 9151756 - hsa-miR-23b-3p chr9 95085265 95085287 + hsa-miR-135a-5p chr12 97563834 97563856 + hsa-miR-195-5p chr17 7017667 7017687 - hsa-miR-34c-5p chr11 111513451 111513473 + hsa-miR-378a-3p chr5 149732867 149732888 + hsa-miR-135b-5p chr1 205448361 205448383 - hsa-miR-422a chr15 63870989 63871010 - hsa-miR-424-5p chrX 134546680 134546701 - hsa-miR-432-5p chr14 100884496 100884518 + hsa-miR-512-3p chr19 53666729 53666750 + hsa-miR-520a-5p chr19 53690895 53690915 + hsa-miR-545-3p chrX 74287126 74287147 - hsa-miR-654-5p chr14 101040234 101040255 + hsa-miR-708-5p chr11 79402077 79402099 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC064802.1 chr8 114282067 114295839 + AD000090.1 chr19 35557956 35581954 + AL117378.1 chr6 131901963 131920565 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 22649065 Title: Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans Author: Mohammad MA, Hadsell DL, Haymond MW. Journal: Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76. Description: We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.