Entry Detail


General Information

Database ID:exR0722522
RNA Name:TPX2
RNA Type:mRNA
Chromosome:chr20
Starnd:+
Coordinate:
Start Site(bp):31739271End Site(bp):31801805
External Links:ENSG00000088325



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AAMP
chr2
218264123
218270257
-
ABHD12
chr20
25294742
25390835
-
ABHD17B
chr9
71862452
71910931
-
AC119674.2
chr1
56173433
56524495
-
AC138811.2
chr16
18788063
18801519
-
ACACB
chr12
109116595
109268226
+
ACADM
chr1
75724347
75787575
+
ACTG1
chr17
81509971
81523847
-
ADD1
chr4
2843857
2930076
+
AGO2
chr8
140520156
140635633
-
AK2
chr1
33007940
33080996
-
AL121594.1
chr14
35122549
35317474
+
ALDOA
chr16
30064164
30070457
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-3654
chr7
133034860
133034878
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC064802.1
chr8
114282067
114295839
+
AC132217.1
chr11
2129121
2129964
-
AL117378.1
chr6
131901963
131920565
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.