Entry Detail


General Information

Database ID:exR0722632
RNA Name:TRIO
RNA Type:mRNA
Chromosome:chr5
Starnd:+
Coordinate:
Start Site(bp):14143342End Site(bp):14532128
External Links:ENSG00000038382



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AAK1
chr2
69457997
69674349
-
AC245033.1
chr15
82536788
82573194
-
ACTG1
chr17
81509971
81523847
-
ACTN1
chr14
68874143
68979440
-
ACTN4
chr19
38647649
38731589
+
ADAMTS1
chr21
26835755
26845409
-
ADCY1
chr7
45574140
45723116
+
ADK
chr10
74151202
74709963
+
AKR7A2
chr1
19303965
19312146
-
AKT2
chr19
40230317
40285536
-
AL138752.2
chr9
37588413
38068687
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-140-5p
chr16
69933103
69933124
+
hsa-miR-34c-5p
chr11
111513451
111513473
+
hsa-miR-490-3p
chr7
136903242
136903263
+
hsa-miR-423-5p
chr17
30117095
30117117
+
hsa-miR-873-5p
chr9
28888925
28888945
-
hsa-miR-1286
chr22
20249145
20249165
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC010442.1
chr5
466124
473098
-
AC114980.1
chr5
93860669
93863825
-
AC144548.1
chr12
110387463
110445548
-
AC245033.4
chr15
82533175
82540008
-
AD000090.1
chr19
35557956
35581954
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.