Entry Detail


General Information

Database ID:exR0723313
RNA Name:WDR74
RNA Type:mRNA
Chromosome:chr11
Starnd:-
Coordinate:
Start Site(bp):62832342End Site(bp):62841809
External Links:ENSG00000133316



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:Day 42 post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AARS2
chr6
44298731
44313347
-
ABCA13
chr7
48171458
48647497
+
ABL2
chr1
179099330
179229684
-
AC005943.1
chr19
1578339
1605445
-
AC006064.6
chr12
6556886
6607367
-
AC011005.1
chr7
129126518
129130793
+
AC011448.1
chr19
19516227
19536076
+
AC126283.2
chr4
109713916
109801999
-
AC245033.1
chr15
82536788
82573194
-
ACO2
chr22
41469117
41528989
+
ACTG1
chr17
81509971
81523847
-
ADARB1
chr21
45073853
45226560
+
AHSA1
chr14
77457870
77469472
+
AKAP12
chr6
151239967
151358559
+
AKR1A1
chr1
45550543
45570049
+
AL136295.4
chr14
24180395
24190416
-
ALDOA
chr16
30064164
30070457
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-155-5p
chr21
25573983
25574006
+
hsa-miR-1246
chr2
176601024
176601042
-
hsa-miR-3609
chr7
98881700
98881723
+
hsa-miR-664b-5p
chrX
154768596
154768619
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC006064.5
chr12
6510275
6510522
+
AC007952.4
chr17
19112000
19112636
-
AC010442.1
chr5
466124
473098
-
AC114781.2
chr4
83233512
83247213
-
AC245014.3
chr1
145281116
145281462
+
AC245033.4
chr15
82533175
82540008
-
AD000090.1
chr19
35557956
35581954
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.