exRNAdisease

Entry Detail

---



General Information

Database ID: exR0749441 RNA Name: hsa-let-7a-5p RNA Type: miRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 94175962 End Site(bp): 94175983 External Links: hsa-let-7a-5p

Disease Information

Disease Name: Lactation Disease Category: Other Diseases MeSH ID: D007774 Type: Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena Alias: Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations

Expression Detail

GEO ID: GSE75726 Description: Human milk cells and lipids conserve numerous known and novel miRNAs, some of which are differentially expressed during lactation Experimental Design: Time Series Case Disease Type: Lactation Case Disease SubType: NA Case Sample: Post-feeding, month 4 of lactation Control Sample: Post-feeding, month 2 of lactation Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HMGA1 chr6 34236873 34246231 + PDPR chr16 70113626 70162537 + ERO1A chr14 52639915 52695900 - UBE2G2 chr21 44768580 44801826 - CD82 chr11 44564427 44620358 + YOD1 chr1 207043849 207052980 - HMGA2 chr12 65824131 65966295 + MYL12A chr18 3247481 3256236 + CTPS2 chrX 16587999 16712936 - MARCKSL1 chr1 32333839 32336233 - AGRN chr1 1020120 1056118 + STK4 chr20 44966479 45080021 + BRD4 chr19 15235519 15332545 - C1orf43 chr1 154206696 154220637 - PLD3 chr19 40348456 40380439 + BACH1 chr21 29194071 29630751 + PPARA chr22 46150521 46243756 + WDR83OS chr19 12668073 12669415 - BCAM chr19 44809071 44821421 + IGF2BP1 chr17 48997385 49056145 + SNRPC chr6 34757505 34773857 + COIL chr17 56938199 56961050 - RANBP2 chr2 108719482 108785809 + ZNF576 chr19 43596392 43601157 + BLOC1S6 chr15 45587214 45615945 + ARHGAP28 chr18 6729718 6915716 + TRIM65 chr17 75880335 75896951 - NHLRC3 chr13 39038306 39050109 + TAF4 chr20 61953469 62065810 - IGDCC3 chr15 65327127 65378002 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000247 chr10 74474868 74475660 + hsa_circ_0000987 chr2 30748452 30756180 + hsa_circ_0000246 chr10 74468040 74475660 + hsa_circ_0000018 chr1 15860731 15863309 + hsa_circ_0000038 chr1 28800065 28802803 + hsa_circ_0000799 chr17 65941524 65972074 + hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC006064.5 chr12 6510275 6510522 + AC074117.1 chr2 27356246 27367622 + AC109460.3 chr16 28974804 28990775 + AC124045.1 chr3 44667412 44669364 + AL359924.1 chr1 237862175 237928321 + AP000766.1 chr11 107312132 107316271 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - KCNQ1OT1 chr11 2608328 2699994 - LINC00265 chr7 39733430 39793092 + LINC02381 chr12 54126082 54147485 + MIRLET7BHG chr22 46053869 46113928 + NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - SNHG16 chr17 76557764 76565348 + SNHG4 chr5 139274102 139284899 + TMPO-AS1 chr12 98512973 98516422 - XIST chrX 73820649 73852723 - ZNF436-AS1 chr1 23368997 23371839 + AD000090.1 chr19 35557956 35581954 + LINC01744 chr1 232727251 232751299 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 27074017 Title: Human Milk Cells and Lipids Conserve Numerous Known and Novel miRNAs, Some of Which Are Differentially Expressed during Lactation Author: Alsaweed M, Lai CT, Hartmann PE, Geddes DT, Kakulas F Journal: PLoS One. 2016 Apr 13;11(4):e0152610. Description: We used deep sequencing to profile miRNAs in the cell and lipid fractions of HM obtained post-feeding from 10 lactating women in months 2, 4, and 6 postpartum.