exRNAdisease

Entry Detail

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General Information

Database ID: exR0753547 RNA Name: AC008124.1 RNA Type: lncRNA Chromosome: chr12 Starnd: - Coordinate: Start Site(bp): 45718046 End Site(bp): 45727775 External Links: ENSG00000273015

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE106804 Description: Engineered Nanointerfaces for Microfluidic Isolation and Molecular Profiling of Tumor-specific Extracellular Vesicles Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 13 Number of Control: 6 Number of Samples: 19

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AP002990.1 chr11 62559603 62591531 - ASPM chr1 197084127 197146694 - ATP5MG chr11 118401606 118431496 + CASP3 chr4 184627696 184649509 - DOCK5 chr8 25184689 25418082 + DOT1L chr19 2163933 2232578 + DUS3L chr19 5784832 5791225 - DYNC1H1 chr14 101964573 102056443 + EEF1G chr11 62559596 62574086 - EIF4G1 chr3 184314495 184335358 + ENO1 chr1 8861000 8879190 - ERLEC1 chr2 53787044 53818819 + FHL1 chrX 136146702 136211359 + GAPDH chr12 6534512 6538374 + HACD3 chr15 65530418 65578349 + HDAC2 chr6 113933028 114011308 - ILK chr11 6603708 6610874 + IRF2BPL chr14 77024543 77028708 - JMJD8 chr16 681670 684528 - MT-ND4 chrMT 10760 12137 + RUVBL2 chr19 48993562 49015970 + SLC46A1 chr17 28394642 28407197 - STX12 chr1 27773219 27824443 + TMEM198 chr2 219543663 219550595 + TNPO1 chr5 72816312 72916733 + UBAP2 chr9 33921693 34048949 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-30a-5p chr6 71403595 71403616 - hsa-miR-30c-5p chr6 71377003 71377025 - hsa-miR-30d-5p chr8 134804919 134804940 - hsa-miR-30b-5p chr8 134800570 134800591 - hsa-miR-30e-5p chr1 40754371 40754392 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AZIN1-AS1 chr8 102864271 103002424 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 29330365 Title: Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Author: Re¨¢tegui E, van der Vos KE, Lai CP, Zeinali M, Atai NA, Aldikacti B, Floyd FP Jr, H Khankhel A, Thapar V, Hochberg FH, Sequist LV, Nahed BV, S Carter B, Toner M, Balaj L, T Ting D, Breakefield XO, Stott SL. Journal: Nat Commun. 2018 Jan 12;9(1):175. Description: Tumor-derived EVs have the potential to be utilized as disease-specific biomarkers, and genes specific to GBM as well as transcripts that are hallmarks for the four genetic subtypes of the disease.