exRNAdisease

Entry Detail

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General Information

Database ID: exR0753822 RNA Name: AC068768.1 RNA Type: lncRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 123262060 End Site(bp): 123262402 External Links: ENSG00000269980

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE106804 Description: Engineered Nanointerfaces for Microfluidic Isolation and Molecular Profiling of Tumor-specific Extracellular Vesicles Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 13 Number of Control: 6 Number of Samples: 19

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PCBP4 chr3 51957454 51974016 - TSC22D1 chr13 44432143 44577147 - AP001458.2 chr11 62649694 62665178 - GAPDH chr12 6534512 6538374 + ATP2B1 chr12 89588049 89709300 - LBHD1 chr11 62662817 62672255 - PSMB5 chr14 23016543 23035230 - ACOX2 chr3 58505136 58537283 - RAB3B chr1 51907956 51990700 - MTRNR2L12 chr3 96617188 96618236 - TOMM20 chr1 235109341 235128837 - RPL27A chr11 8682788 8714759 + RBMX chrX 136848004 136880764 - SENP2 chr3 185582496 185633551 + RPL13 chr16 89560657 89566828 + CPSF7 chr11 61402641 61430031 - MRPL17 chr11 6680385 6683340 - RAB7A chr3 128726183 128814798 + WDR70 chr5 37379285 37753435 + GATA6 chr18 22169392 22202528 + CCDC28B chr1 32200386 32205387 + UNC45A chr15 90930180 90954093 + CLDN4 chr7 73799542 73832693 + RPS24 chr10 78033760 78056813 + HSH2D chr19 16134028 16158575 + TSPAN6 chrX 100627108 100639991 - RPL39 chrX 119786504 119791630 - RDX chr11 109864295 110296712 - ACTG1 chr17 81509971 81523847 - BROX chr1 222712553 222735196 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-21-5p chr17 59841273 59841294 + hsa-miR-26a-5p chr3 37969413 37969434 + hsa-miR-26b-5p chr2 218402657 218402677 + hsa-miR-105-5p chrX 152394458 152394480 - hsa-miR-139-5p chr11 72615102 72615124 - hsa-miR-432-5p chr14 100884496 100884518 + hsa-miR-524-5p chr19 53711017 53711038 + hsa-miR-520d-5p chr19 53720111 53720130 + hsa-miR-582-5p chr5 59703666 59703688 - hsa-miR-590-5p chr7 74191213 74191234 + hsa-miR-650 chr22 22822791 22822811 + hsa-miR-1297 chr13 54311981 54311997 - hsa-miR-3612 chr12 128294105 128294126 + hsa-miR-4465 chr6 140683855 140683876 + hsa-miR-5579-3p chr11 79422169 79422190 - hsa-miR-7853-5p chr6 6169380 6169400 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007996.1 chr18 26542971 26545791 - AC125807.2 chr12 3041437 3044950 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 29330365 Title: Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Author: Re¨¢tegui E, van der Vos KE, Lai CP, Zeinali M, Atai NA, Aldikacti B, Floyd FP Jr, H Khankhel A, Thapar V, Hochberg FH, Sequist LV, Nahed BV, S Carter B, Toner M, Balaj L, T Ting D, Breakefield XO, Stott SL. Journal: Nat Commun. 2018 Jan 12;9(1):175. Description: Tumor-derived EVs have the potential to be utilized as disease-specific biomarkers, and genes specific to GBM as well as transcripts that are hallmarks for the four genetic subtypes of the disease.