exRNAdisease

Entry Detail

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General Information

Database ID: exR0755061 RNA Name: MIR4435-2HG RNA Type: lncRNA Chromosome: chr2 Starnd: - Coordinate: Start Site(bp): 111006015 End Site(bp): 111523376 External Links: ENSG00000172965

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE106804 Description: Engineered Nanointerfaces for Microfluidic Isolation and Molecular Profiling of Tumor-specific Extracellular Vesicles Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 13 Number of Control: 6 Number of Samples: 19

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-105-5p chrX 152394458 152394480 - hsa-miR-1-3p chr18 21829015 21829036 - hsa-miR-128-3p chr2 135665446 135665466 + hsa-miR-136-5p chr14 100884716 100884738 + hsa-miR-193a-3p chr17 31560050 31560071 + hsa-miR-206 chr6 52144401 52144422 + hsa-miR-193b-3p chr16 14304017 14304038 + hsa-miR-503-5p chrX 134546371 134546393 - hsa-miR-513a-5p chrX 147213538 147213555 - hsa-miR-873-5p chr9 28888925 28888945 - hsa-miR-3611 chr10 35079609 35079629 - hsa-miR-3681-3p chr2 12199174 12199195 + hsa-miR-4525 chr17 82668281 82668301 - hsa-miR-2467-3p chr2 239351732 239351753 - hsa-miR-5010-5p chr17 42514208 42514229 + hsa-miR-873-3p chr9 28888889 28888910 - hsa-miR-216a-3p chr2 55988981 55989002 - hsa-miR-7853-5p chr6 6169380 6169400 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC017002.1 chr2 111607841 111612518 + AC133644.3 chr2 87455476 87767359 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 29330365 Title: Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Author: Re¨¢tegui E, van der Vos KE, Lai CP, Zeinali M, Atai NA, Aldikacti B, Floyd FP Jr, H Khankhel A, Thapar V, Hochberg FH, Sequist LV, Nahed BV, S Carter B, Toner M, Balaj L, T Ting D, Breakefield XO, Stott SL. Journal: Nat Commun. 2018 Jan 12;9(1):175. Description: Tumor-derived EVs have the potential to be utilized as disease-specific biomarkers, and genes specific to GBM as well as transcripts that are hallmarks for the four genetic subtypes of the disease.