exRNAdisease

Entry Detail

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General Information

Database ID: exR0755587 RNA Name: AKT2 RNA Type: mRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 40230317 End Site(bp): 40285536 External Links: ENSG00000105221

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE106804 Description: Engineered Nanointerfaces for Microfluidic Isolation and Molecular Profiling of Tumor-specific Extracellular Vesicles Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 13 Number of Control: 6 Number of Samples: 19

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SHC1 chr1 154962298 154974395 - COLGALT1 chr19 17555649 17583162 + UNC13B chr9 35161992 35405338 + SERTAD2 chr2 64631621 64751005 - CIC chr19 42268537 42295797 + ZNF100 chr19 21722771 21767579 - TSPAN3 chr15 77041404 77083984 - CIT chr12 119685791 119877320 - TTLL4 chr2 218710835 218755416 + AL589666.1 chr6 85557978 85615234 - NFAT5 chr16 69565094 69704666 + GSK3A chr19 42230190 42242625 - SMG5 chr1 156249224 156282825 - PCBP4 chr3 51957454 51974016 - TFAP4 chr16 4257186 4273075 - SNX12 chrX 71056332 71073426 - SCAF1 chr19 49642209 49658642 + ACTG1 chr17 81509971 81523847 - PRKCE chr2 45651345 46187990 + RPS19 chr19 41860255 41872925 + ZNF317 chr19 9140397 9163424 + UBE2D2 chr5 139526431 139628434 + SPEN chr1 15836095 15940456 + SYNCRIP chr6 85607785 85643792 - NONO chrX 71283192 71301168 + DDX51 chr12 132136594 132144319 - FBXO11 chr2 47789316 47905793 - CFL1 chr11 65823022 65862026 - RGS1 chr1 192575763 192580024 + EEF1G chr11 62559596 62574086 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-485-5p chr14 101055427 101055448 + hsa-miR-641 chr19 40282603 40282626 - hsa-miR-650 chr22 22822791 22822811 + hsa-miR-671-5p chr7 151238449 151238471 + hsa-miR-423-5p chr17 30117095 30117117 + hsa-miR-1224-5p chr3 184241405 184241423 + hsa-miR-1294 chr5 154347153 154347174 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC012321.1 chr16 69703065 69704652 + AC012510.1 chr2 218633256 218634014 - AC020663.1 chr16 4730115 4752565 - AC091564.7 chr11 6610883 6616594 - AC093249.6 chr16 30697707 30699058 - AC109460.3 chr16 28974804 28990775 + AC118344.1 chr19 40273489 40275479 - AD000090.1 chr19 35557956 35581954 + AL355075.4 chr14 20343048 20343685 - AL589642.1 chr9 32633454 32648685 + DANCR chr4 52712404 52720351 + HCG18 chr6 30286690 30327382 - LINC01002 chr19 198264 246544 - NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 29330365 Title: Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Author: Re¨¢tegui E, van der Vos KE, Lai CP, Zeinali M, Atai NA, Aldikacti B, Floyd FP Jr, H Khankhel A, Thapar V, Hochberg FH, Sequist LV, Nahed BV, S Carter B, Toner M, Balaj L, T Ting D, Breakefield XO, Stott SL. Journal: Nat Commun. 2018 Jan 12;9(1):175. Description: Tumor-derived EVs have the potential to be utilized as disease-specific biomarkers, and genes specific to GBM as well as transcripts that are hallmarks for the four genetic subtypes of the disease.