exRNAdisease

Entry Detail

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General Information

Database ID: exR0755605 RNA Name: ALDH5A1 RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 24494867 End Site(bp): 24537207 External Links: ENSG00000112294

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE106804 Description: Engineered Nanointerfaces for Microfluidic Isolation and Molecular Profiling of Tumor-specific Extracellular Vesicles Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 13 Number of Control: 6 Number of Samples: 19

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand YWHAB chr20 44885702 44908532 + B2M chr15 44711487 44718877 + SLC25A6 chrX 1386152 1392113 - MAP7D1 chr1 36155579 36180849 + TTC19 chr17 15999784 16045015 + EIF3E chr8 108201216 108435333 - FBRSL1 chr12 132489551 132585188 + IRF2BP2 chr1 234604269 234609525 - USP53 chr4 119212587 119295517 + SH3GLB2 chr9 129007036 129028303 - MYO10 chr5 16661907 16936288 - TET3 chr2 73986404 74108176 + STK11IP chr2 219597857 219616451 + NFKB2 chr10 102394110 102402524 + MAPK12 chr22 50245450 50261716 - ERRFI1 chr1 8004404 8026309 - PNMA2 chr8 26504701 26514092 - HUWE1 chrX 53532096 53686728 - GTF2F1 chr19 6379572 6393981 - RPS6 chr9 19375715 19380236 - RPL37A chr2 216498825 216579180 + SLX1A chr16 30193887 30197561 + BAX chr19 48954815 48961798 + IGF2 chr11 2129112 2141238 - KLC4 chr6 43040777 43075095 + ZNF33A chr10 38010650 38065088 + ZNF12 chr7 6688433 6706947 - LASP1 chr17 38869859 38921770 + RPL13 chr16 89560657 89566828 + FAM104B chrX 55143102 55161310 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-129-5p chr7 128207876 128207896 + hsa-miR-330-5p chr19 45639049 45639070 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022201.2 chr2 70301451 70302072 + AL645941.1 chr6 32970232 32970886 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 29330365 Title: Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Author: Re¨¢tegui E, van der Vos KE, Lai CP, Zeinali M, Atai NA, Aldikacti B, Floyd FP Jr, H Khankhel A, Thapar V, Hochberg FH, Sequist LV, Nahed BV, S Carter B, Toner M, Balaj L, T Ting D, Breakefield XO, Stott SL. Journal: Nat Commun. 2018 Jan 12;9(1):175. Description: Tumor-derived EVs have the potential to be utilized as disease-specific biomarkers, and genes specific to GBM as well as transcripts that are hallmarks for the four genetic subtypes of the disease.