exRNAdisease

Entry Detail

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General Information

Database ID: exR0761908 RNA Name: PFN1 RNA Type: mRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 4945652 End Site(bp): 4949061 External Links: ENSG00000108518

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE106804 Description: Engineered Nanointerfaces for Microfluidic Isolation and Molecular Profiling of Tumor-specific Extracellular Vesicles Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 13 Number of Control: 6 Number of Samples: 19

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AFAP1 chr4 7758714 7939926 - ADGRA3 chr4 22345071 22516066 - AGFG1 chr2 227472152 227561214 + AJM1 chr9 136844415 136848801 + ADD1 chr4 2843857 2930076 + AC099489.1 chr16 11359845 11527245 - AL139011.2 chr1 160216800 160285130 - ACOX2 chr3 58505136 58537283 - AC139530.2 chr17 81703371 81720539 + AC104109.3 chr5 134167170 134226071 - AC099811.2 chr17 42119674 42154916 - AC092143.1 chr16 89919165 89936092 + ALDOA chr16 30064164 30070457 + ACSS2 chr20 34872146 34927962 + ABCD4 chr14 74285269 74303055 - AGA chr4 177430774 177442437 - AC073508.2 chr17 40627356 40665141 - AIFM1 chrX 130129362 130165887 - AL121594.1 chr14 35122549 35317474 + AC005258.1 chr19 2269525 2341172 + AGRN chr1 1020120 1056118 + AGPAT5 chr8 6708642 6761503 + ABCG2 chr4 88090150 88231628 - ACTA1 chr1 229431245 229434098 - ADAM10 chr15 58588809 58749791 - AGPAT1 chr6 32168212 32178096 - AHCY chr20 34280268 34311802 - ACTB chr7 5527148 5563784 - AC004922.1 chr7 99325879 99394653 + AC008763.3 chr19 7678501 7682854 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-320a-3p chr8 22244975 22244996 - hsa-miR-330-3p chr19 45639009 45639031 - hsa-miR-320b chr1 224257049 224257070 - hsa-miR-320c chr18 24321716 24321735 + hsa-miR-320d chr13 40727828 40727846 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC016876.2 chr17 7581964 7584086 - AC020663.1 chr16 4730115 4752565 - AC022031.2 chr18 55589904 55839184 + AC023509.1 chr12 53441741 53467528 + AC026362.1 chr12 122975320 122982907 + AC060780.1 chr17 43148368 43171037 - AC109460.3 chr16 28974804 28990775 + AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + AL023653.1 chrX 129794994 129796963 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 29330365 Title: Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Author: Re¨¢tegui E, van der Vos KE, Lai CP, Zeinali M, Atai NA, Aldikacti B, Floyd FP Jr, H Khankhel A, Thapar V, Hochberg FH, Sequist LV, Nahed BV, S Carter B, Toner M, Balaj L, T Ting D, Breakefield XO, Stott SL. Journal: Nat Commun. 2018 Jan 12;9(1):175. Description: Tumor-derived EVs have the potential to be utilized as disease-specific biomarkers, and genes specific to GBM as well as transcripts that are hallmarks for the four genetic subtypes of the disease.